To review the pathologic and clinical features of and establish the frequency of cytomegalovirus encephalitis in adults and to review the methods available for diagnosis and treatment.
MEDLINE search of all English-language articles from January 1965 to August 1995.
Articles dealing with cytomegalovirus infection of the brain in adults.
We also reviewed all unselected autopsies of these populations to establish the frequency of cytomegalovirus encephalitis in recipients of organ transplants and in patients infected with the human immunodeficiency virus (HIV).
Epidemiologic and pathologic characteristics, clinical manifestations, diagnostic methods, pathogenetic mechanisms, and use of anticytomegalovirus treatments.
Of 676 patients receiving a diagnosis of cytomegalovirus encephalitis, 574 (85%) were infected with HIV, 81 (12%) had other causes of immunosuppression, and 21 (3%) were otherwise healthy.
Cytomegalovirus encephalitis was confirmed during autopsy in 12% of HIV-infected patients and 2% of transplant recipients.
The most common lesion was microglial nodule encephalitis, but the clinical findings corresponding to this pathologic entity are not well defined. (...)
Mots-clés Pascal : Encéphalite, Cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, Virose, Infection, Homme, Diagnostic, Epidémiologie, Association, SIDA, Immunodépression, Transplantation, Infection opportuniste, Traitement, Pronostic, Synthèse bibliographique, Encéphale pathologie, Système nerveux pathologie, Système nerveux central pathologie, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Encephalitis, Cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, Viral disease, Infection, Human, Diagnosis, Epidemiology, Association, AIDS, Immunosuppression, Transplantation, Opportunistic infection, Treatment, Prognosis, Bibliographic survey, Cerebral disorder, Nervous system diseases, Central nervous system disease, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0464213
Code Inist : 002B05C02A. Création : 10/04/1997.