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  1. Risk factor profiles in patients with different clinical manifestations of venous thromboembolism : A focus on the factor V Leiden mutation.

    Article - En anglais

    Background

    Patients with venous thromboembolic disease may present with different clinical manifestations.

    Factor V Leiden mutation leading to resistance to activated protein C is associated with a seven-fold increased risk for presenting with deep-vein thrombosis.

    It is not yet established whether carriers of the mutation have a similarly increased risk for manifesting with pulmonary embolism.

    Methods

    From an Anticoagulation Clinic monitoring coumarin therapy, a consecutive series of patients with a first thromboembolic event (objectively proven by current radiological methods) were enrolled.

    All patients were interviewed and blood was drawn for genotyping.

    From the hospital charts and the personal interview, information was obtained on acquired risk factors and the signs and symptoms on hospital admission.

    Results

    45 patients presented with symptoms of pulmonary embolism only, 211 had only symptoms of deep-vein thrombosis whereas 23 had clinical features of both.

    In about half of the patients acquired risk factors for venous thromboembolism were present which did not differ between the three groups of patients.

    Recent surgery had been performed more often in patients presenting with pulmonary embolism than in other patients (33.3% vs. 18.5%, p<0,05).

    Factor V Leiden was present in 9% of the patients presenting with pulmonary embolism (relative risk : 3.3 95% CI : 1.0-10.6) and 17% of the patients presenting with deep-vein thrombosis (relative risk : 6. (...)

    Mots-clés Pascal : Thromboembolie, Veine, Facteur risque, Symptomatologie, Epidémiologie, Pays Bas, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Facteur V Leiden

    Mots-clés Pascal anglais : Thromboembolism, Vein, Risk factor, Symptomatology, Epidemiology, Netherlands, Europe, Human, Cardiovascular disease, Vascular disease, Venous disease, Factor Leiden

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0463455

    Code Inist : 002B12B03. Création : 10/04/1997.