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  1. Allergen sensitization and exposure to irritants in infancy.

    Article - En anglais

    We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age).

    Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens.

    The median exposures to sulphur dioxide and fluoride during the pollen season in the age interval 19-36 months were 24 and 3.1 mug/m3 in the spring and 20 and 3.3 mug/m3 in the summer, respectively.

    The odds ratio (OR) of having atopy was 2.0 (95% CI : 1.2-3.3) in those children who had lived in the index area for 7 years or more compared with those who had lived there less than 7 years (cumulative effect).

    The OR of atopy was 2.5 (1.4-4.4) in those who had lived in the index area during the age interval of 19-36 months compared with rural residence during this age-interval (age-specific effect).

    When the age-specific effect and the cumulative effect were compared in the same logistic model, the former decreased to 1.1 (0.4-3.0), whereas the latter was 2.2 (0.7-6.6).

    The results indicate that exposure to these low levels of irritants during early childhood increases allergen sensitization in children.

    Mots-clés Pascal : Atopie, Soufre dioxyde, Fluorure, Prévalence, Epidémiologie, Composé irritant, Allergène, Sensibilisation, Exposition, Pollen, Norvège, Europe, Enfant, Homme, Immunopathologie, Allergie

    Mots-clés Pascal anglais : Atopy, Sulfur dioxide, Fluorides, Prevalence, Epidemiology, Irritant compound, Allergen, Sensitization, Exposure, Pollen, Norway, Europe, Child, Human, Immunopathology, Allergy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0461343

    Code Inist : 002B06C01. Création : 10/04/1997.