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  1. Insulin sensitivity and blood pressure in a biethnic sample : The Miami community health study.

    Article - En anglais

    An association between blood pressure and insulin sensitivity among normotensive African-Americans has not been demonstrated consistently in epidemiologic studies.

    Part of the discrepancy may be due to studying persons with profound obesity-an insulin-resistant state itself.

    The association between insulin-mediated glucose uptake (i.e., insulin sensitivity) and blood pressure was examined among 25 nondiabetic African-American and 28 white non-Hispanic persons aged 25-44 years who ranged from normal weight to obese, using the hyperinsulinemic euglycemic clamp technique.

    In bivariate analyses, insulin sensitivity was inversely related to systolic (p<0.01) and diastolic blood pressure (p=0.08) among African-American persons and to diastolic blood pressure among white non-Hispanic subjects (p<0.05).

    Covariate adjustment for age and sex had only a marginal effect on these results.

    When the data were pooled and further adjusted for ethnicity, insulin sensitivity remained significantly associated with both systolic and diastolic blood pressure (p<0.01 for each).

    To consider the effect of obesity, body mass index (BMI) was divided at the sample median (26.5 kg/m2) and the analyses were repeated within each stratum.

    Among those whose BMI was below the median value, each increment in insulin sensitivity was associated with a 2-mmHg decrease in systolic blood pressure (p=0.02). (...)

    Mots-clés Pascal : Insuline, Hormone pancréatique, Hormone protéine, Pression sanguine, Hémodynamique, Ethnie, Noir américain, Caucasoïde, Epidémiologie, Floride, Etats Unis, Amérique du Nord, Amérique, Homme

    Mots-clés Pascal anglais : Insulin, Pancreatic hormone, Protein hormone, Blood pressure, Hemodynamics, Ethnic group, Black American, Caucasoid, Epidemiology, Florida, United States, North America, America, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0460643

    Code Inist : 002B29A. Création : 10/04/1997.