An association between blood pressure and insulin sensitivity among normotensive African-Americans has not been demonstrated consistently in epidemiologic studies.
Part of the discrepancy may be due to studying persons with profound obesity-an insulin-resistant state itself.
The association between insulin-mediated glucose uptake (i.e., insulin sensitivity) and blood pressure was examined among 25 nondiabetic African-American and 28 white non-Hispanic persons aged 25-44 years who ranged from normal weight to obese, using the hyperinsulinemic euglycemic clamp technique.
In bivariate analyses, insulin sensitivity was inversely related to systolic (p<0.01) and diastolic blood pressure (p=0.08) among African-American persons and to diastolic blood pressure among white non-Hispanic subjects (p<0.05).
Covariate adjustment for age and sex had only a marginal effect on these results.
When the data were pooled and further adjusted for ethnicity, insulin sensitivity remained significantly associated with both systolic and diastolic blood pressure (p<0.01 for each).
To consider the effect of obesity, body mass index (BMI) was divided at the sample median (26.5 kg/m2) and the analyses were repeated within each stratum.
Among those whose BMI was below the median value, each increment in insulin sensitivity was associated with a 2-mmHg decrease in systolic blood pressure (p=0.02). (...)
Mots-clés Pascal : Insuline, Hormone pancréatique, Hormone protéine, Pression sanguine, Hémodynamique, Ethnie, Noir américain, Caucasoïde, Epidémiologie, Floride, Etats Unis, Amérique du Nord, Amérique, Homme
Mots-clés Pascal anglais : Insulin, Pancreatic hormone, Protein hormone, Blood pressure, Hemodynamics, Ethnic group, Black American, Caucasoid, Epidemiology, Florida, United States, North America, America, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0460643
Code Inist : 002B29A. Création : 10/04/1997.