Higher white blood cell counts in smokers compared with nonsmokers have been well documented, but the longitudinal relation between changes in smoking and changes in white blood cells has not been well described.
Since 1984, data have been collected semiannually by the Multicenter AIDS Cohort Study (MACS), a four-center prospective cohort study of acquired immunodeficiency syndrome (AIDS) in homosexual men.
The study population includes 2,435 participants who were human immunodeficiency virus (HIV) seronegative as of September 1994 and who contributed 20,918 person-visits for this analysis.
For individuals who modified their smoking behavior, changes in white blood cell counts occurred primarily during the first 6 months following changes in the amount of cigarettes smoked.
Among former smokers who resumed smoking, the extent of the increase in white blood cell count depended on the number of cigarettes smoked.
Specifically, increases of 241,340, and 740 cells/muliter were observed for smokers who resumed smoking<1,1 to<2, and =2 packs/day, respectively.
Conversely, smokers who quit smoking had a decrease of white blood cell count : 32, - 629, and - 1,122 cells/muliter for men who previously smoked<1,1 to<2, and =2 packs/day, respectively.
Long-term ex-smokers, however, still had higher white blood cell counts than did never smokers.
There was a high within-individual correlation of white blood cell count in persons who reported a consistent level of smoking (i.e. (...)
Mots-clés Pascal : Tabagisme, Toxicité, Leucocyte, Numération, Homme, Epidémiologie, Changement comportement, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Tobacco smoking, Toxicity, Leukocyte, Numeration, Human, Epidemiology, Behavior change, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0459832
Code Inist : 002B03E. Création : 10/04/1997.