Proto-oncogenes are genes coding for factors involved in cellular growth, reproduction, and differentiation.
Cancer results through mutations of proto-oncogenes or through other mechanisms involving the products of proto-oncogenes.
This study asks whether serum proteins immunologically related to the products of proto-oncogenes distinguish older men and women who manifest a new cancer during a 2-year follow-up.
The authors conducted a nested case-control study that involved 248 men and women selected from a larger group of older (age =65 years) healthy volunteers in a randomized clinical trial of preventive clinical services.
Study subjects included 37 with a fatal cancer, 59 non-fatal breast, prostate, colon, or lung cancer, 58 hospitalized with at least one discharge diagnosis that coded to benign neoplasia (International Classification of Diseases, 9th Revision codes 210-239), and 94 randomly selected controls.
Using seven monoclonal antibodies prepared against ras, erb-B, FES, myb, and SIS polypeptide sequences, immunoblots detected 17 proteins in serum collected from subjects before the clinical recognition of cancer.
Five oncogene-related serum proteins appeared to distinguish older persons who manifested fatal (but not non-fatal) cancer over a brief (2-year) follow-up.
Older persons hospitalized with benign neoplasia also had higher levels of these serum proteins.
Relative to the 94 control subjects, a 52,000 dalton SIS-related protein (odd ratio (OR)=5. (...)
Mots-clés Pascal : Tumeur maligne, Epidémiologie, Protéine sérique, Protooncogène, Gène onc, Vieillard, Homme, Facteur risque, Pennsylvanie, Etats Unis, Amérique du Nord, Amérique, Gène ras, Gène erbB, Gène myb, Gène fes, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Epidemiology, Serum protein, Protooncogene, Onc gene, Elderly, Human, Risk factor, Pennsylvania, United States, North America, America, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0459830
Code Inist : 002B04B. Création : 10/04/1997.