Effect of maternal age and parity on the risk of uteroplancental bleeding disorders in pregnancy.
To examine the risk of placental abruption, placenta previa, and uterine bleeding of unknown etiology in relation to advanced maternal age and parity in a large, population-based study.
Data for this study were derived from the Nova Scotia Atlee perinatal provincial data base, Canada, an ongoing project on human reproduction.
Women who delivered between 1980 and 1993 (n=123,941) in the province of Nova Scotia were included in the study, with the exception of pregnancies resulting in multiple births (n=2859) and those missing data on maternal age or parity (n=14).
Multivariable logistic regression models based on the method of generalized estimating equations were used to generate odds ratios after adjustment for multiple confounders.
The frequency of abruption was increased slightly among younger women (relative risk [RR] 1.3,95% confidence interval [CI] 1.0-1.7), compared with women ages 25-29 years, but there was no increase with advancing maternal age.
In contrast, the risk of placenta previa increased dramatically with advancing maternal age, with women older than 40 years having a nearly ninefold greater risk than women under the age of 20, after adjustment for potential confounders, including parity.
Uterine bleeding of unknown etiology was not associated with advanced maternal age, except for a slight increase among women over 40 (RR 1.3,95% CI 1.0-1.6). (...)
Mots-clés Pascal : Gestation, Complication, Hémorragie, Utérus, Placenta, Facteur risque, Age mère, Parité, Etude statistique, Homme, Femelle, Gestation pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Appareil génital femelle pathologie, Utérus pathologie, Placenta pathologie
Mots-clés Pascal anglais : Pregnancy, Complication, Hemorrhage, Uterus, Placenta, Risk factor, Maternal age, Parity, Statistical study, Human, Female, Pregnancy disorders, Cardiovascular disease, Vascular disease, Female genital diseases, Uterine diseases, Placenta diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0459527
Code Inist : 002B20F02. Création : 10/04/1997.