Determinants of bone and blood lead levels among community-exposed middle-aged to elderly men : The normative aging study.
Levels of lead in bone serve as a dosimeter for cumulative exposure to lead ; moreover, lead in bone may serve as an internal source of circulating lead many years after environmental exposure has ceased.
The authors measured lead in blood and used a K-x-ray fluorescence instrument to measure lead in the tibia (cortical) and patella (trabecular) bones in a cross-sectional survey of 719 middle-aged to elderly male participants in the Normative Aging Study who were without unusual occupational exposures to lead and who were healthy when enrolled in 1962-1965.
Blood lead levels ranged from<1 to 27.9 mug/dl, with a geometric mean of 5.7 mug/dl.
Tibia and patella lead level ranges (geometric means) were<1-51 (20.8) mug/g and 3-77 (29.8) mug/g, respectively.
In backwards elimination multivariate regression models that considered age, race, education, retirement status, measures of both current and cumulative smoking, and alcohol consumption, the factors that remained significantly related to higher levels of both tibia and patella lead were higher age and measures of cumulative smoking, and lower levels of education.
In the final model predicting blood lead that began with these same covariates and also included tibia and patella lead, the factor that accounted for the dominant portion of the variance in blood lead was patella lead. (...)
Mots-clés Pascal : Plomb, Métal lourd, Taux, Os, Sang, Homme, Vieillard, Mâle, Environnement, Pollution, Epidémiologie, Age, Race, Niveau étude, Etats Unis, Amérique du Nord, Amérique, Retraite, Mode de vie
Mots-clés Pascal anglais : Lead, Heavy metal, Rate, Bone, Blood, Human, Elderly, Male, Environment, Pollution, Epidemiology, Age, Race, Education level, United States, North America, America, Retirement, Life habit
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0459249
Code Inist : 002B03L05. Création : 10/04/1997.