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  1. Nonoxynol-9 in lubricated condoms : Results of a study in female prostitutes.

    Article - En anglais

    Background and Objectives 

    Debate continues on the efficacy and safety of intravaginal nonoxynol-9 for the prevention of horizontal transmission of human immunodeficiency and other sexually transmitted diseases.

    Little attention has been paid to the effects of nonoxynol-9 contained in the lubricant of many condoms.

    Goal : To assess the tolerability of different levels of nonoxynol-9 in condom lubricants.

    Study Design 

    Pilot, randomized, controlled trial in 70 female prostitutes.


    There was no association between dose of nonoxynol-9 and reported symptoms or signs of genital tract inflammation ; an increased dose of nonoxynol-9 was associated with increased numbers of polymorphonuclear leukocytes on a vaginal wall smear.


    There is no recognized simple method of defining inflammation in the female genital tract.

    Future studies of the effects of low-dose nonoxynol-9 on the female genital tract require highly controlled exposures, plus colposcopy with or without vaginal biopsy to define inflammation.

    Mots-clés Pascal : Condom, Tolérance, Toxicité, Voie administration, Antiviral, In vitro, Lubrifiant, Lubrification, Dose faible, Homme, Femelle, Appareil génital femelle, Inflammation, Nonoxynol-9

    Mots-clés Pascal anglais : Condom, Tolerance, Toxicity, Route of administration, Antiviral, In vitro, Lubricant, Lubrication, Low dose, Human, Female, Female genital system, Inflammation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0458569

    Code Inist : 002B30A03B. Création : 10/04/1997.