Nonoxynol-9 in lubricated condoms : Results of a study in female prostitutes.
Background and Objectives
Debate continues on the efficacy and safety of intravaginal nonoxynol-9 for the prevention of horizontal transmission of human immunodeficiency and other sexually transmitted diseases.
Little attention has been paid to the effects of nonoxynol-9 contained in the lubricant of many condoms.
Goal : To assess the tolerability of different levels of nonoxynol-9 in condom lubricants.
Pilot, randomized, controlled trial in 70 female prostitutes.
There was no association between dose of nonoxynol-9 and reported symptoms or signs of genital tract inflammation ; an increased dose of nonoxynol-9 was associated with increased numbers of polymorphonuclear leukocytes on a vaginal wall smear.
There is no recognized simple method of defining inflammation in the female genital tract.
Future studies of the effects of low-dose nonoxynol-9 on the female genital tract require highly controlled exposures, plus colposcopy with or without vaginal biopsy to define inflammation.
Mots-clés Pascal : Condom, Tolérance, Toxicité, Voie administration, Antiviral, In vitro, Lubrifiant, Lubrification, Dose faible, Homme, Femelle, Appareil génital femelle, Inflammation, Nonoxynol-9
Mots-clés Pascal anglais : Condom, Tolerance, Toxicity, Route of administration, Antiviral, In vitro, Lubricant, Lubrication, Low dose, Human, Female, Female genital system, Inflammation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0458569
Code Inist : 002B30A03B. Création : 10/04/1997.