To describe the association between hormonally related risk factors and the progression to new sites of radiographically defined full body (generalized) osteoarthritis (OA) in a cohort of older women.
A retrospective cohort design was used to study former radium dial painters over the age of 40 years who had minimal radium exposure.
At study entry and at varying followup times, clinical examinations were conducted and full body radiographs were taken.
Two followup groups were defined : women with a followup radiograph 1-9 years after baseline (n=75) and 10-19 years after baseline (n=53).
Fifty-five joints (10 joint groups) were independently graded at baseline and followup for OA by the method of Kellgren and Lawrence, and provided the basis for summary full body OA progression scores.
Progression was defined as an increase in the number of sites with OA and in separate analyses as an increase in the number of joint groups with OA.
Increasing length of followup and lower baseline OA score were associated with greater OA progression, while age at baseline examination showed no clear relation to progression.
Beyond these variables, increasing height and having ever smoked were inversely associated with OA progression, while body mass index (BMI) showed a weak positive association.
In multivariable modeling for followup 1-9 years, only lower baseline OA score predicted greater OA progression to new sites (partial r2=0.13, p=0.0009). (...)
Mots-clés Pascal : Arthrose, Homme, Femelle, Evolution, Age, Facteur risque, Epidémiologie, Etude longitudinale, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative
Mots-clés Pascal anglais : Osteoarthritis, Human, Female, Evolution, Age, Risk factor, Epidemiology, Follow up study, Diseases of the osteoarticular system, Arthropathy, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0458234
Code Inist : 002B15E. Création : 10/04/1997.