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  1. Absence of human immunodeficiency virus type 2 infection among patients in a hospital serving a New York community at high risk for infection.

    Article - En anglais

    Background 

    Although human immunodeficiency virus type 2 (HIV-2) infection among United States residents is considered rare, there are US populations at high risk.

    Few studies have surveyed these populations with a high likelihood of infection, that is, those with high percentages of persons from HIV-2-endemic areas and high prevalences of behaviors that would allow for transmission.

    Study Design and Methods 

    Patients (n=832) enrolled in a confidential HIV serosurvey at a hospital that serves a community with a relatively high percentage of WestAfrican immigrants, drug injectors, and persons who practice high-risk sexual activity were evaluated.

    Sera were tested for HIV type 1 (HIV-1) and HIV-2 by rapid enzyme immunoassays, standard enzyme immunoassays and Western blots.

    Results 

    Eight of 832 patients were weakly reactive to HIV-2 on rapid assay, but none was confirmed to be infected when tested by standard immunoassay and Western blot.

    Five of these eight were reactive to HIV-1.

    Conclusion 

    Weak reactivity to HIV-2 antibody on the rapid assay is best explained by cross-reactivity with HIV-1 antibody ; thus, even in this population at high risk for infection, false-positive reactions are more likely than true infections.

    The finding that HIV-2 is absent in this population at potentially high risk for infection corroborates the findings of other studies that HIV-2 infection is rare among US residents. (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV2, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Risque, Milieu hospitalier, Sérologie, Surveillance, Epidémiologie, Homme, New York, Etats Unis, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-2 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Risk, Hospital environment, Serology, Surveillance, Epidemiology, Human, New York, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0452207

    Code Inist : 002B06D01. Création : 10/04/1997.