logo BDSP

Base documentaire

  1. Grouped caging predisposes male mice to ankylosing enthesopathy.

    Article - En anglais


    To evaluate the number of males per cage as a possible risk factor for murine ankylosing enthesopathy (ANKENT) - a spontaneous joint disease with parallels to human seronegative spondylarthropathies-since ANKENT shows incomplete penetrance of genetic susceptibility factors among individuals living in a stable environment.

    Methods-Frequency of ANKENT was compared among males housed with females, with other males, or alone.


    In three independent cohorts, a trend was observed that males housed with females rarely develop the disease, in contrast to males housed with other males (P<0.25, P<0.05, and P<0.01).

    Furthermore, no males caged alone developed ANKENT, whereas disease did occur in males grouped together (P<0.01).

    When healthy males (retired breeders) were recaged either alone or with other males, ANKENT developed among the grouped males only (P<0.005).

    Conclusions-Caging males together is a relative risk factor for ANKENT.

    Grouped caging may perturb the immune system through endocrine pathways or modify microbiological load through behaviour (for example, infection due to biting).

    Mots-clés Pascal : Spondylarthropathie, Modèle animal, Rat, Rodentia, Mammalia, Vertebrata, Mâle, Facteur risque, Epidémiologie, Exposition, Sexe, Groupage, Rhumatisme inflammatoire, Système ostéoarticulaire pathologie, Rachis pathologie, Juxtaarticulaire pathologie, Enthésopathie

    Mots-clés Pascal anglais : Spondylarthropathy, Animal model, Rat, Rodentia, Mammalia, Vertebrata, Male, Risk factor, Epidemiology, Exposure, Sex, Grouping, Inflammatory joint disease, Diseases of the osteoarticular system, Spine disease, Juxtaarticular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0451901

    Code Inist : 002B15D. Création : 10/04/1997.