Grouped caging predisposes male mice to ankylosing enthesopathy.
To evaluate the number of males per cage as a possible risk factor for murine ankylosing enthesopathy (ANKENT) - a spontaneous joint disease with parallels to human seronegative spondylarthropathies-since ANKENT shows incomplete penetrance of genetic susceptibility factors among individuals living in a stable environment.
Methods-Frequency of ANKENT was compared among males housed with females, with other males, or alone.
In three independent cohorts, a trend was observed that males housed with females rarely develop the disease, in contrast to males housed with other males (P<0.25, P<0.05, and P<0.01).
Furthermore, no males caged alone developed ANKENT, whereas disease did occur in males grouped together (P<0.01).
When healthy males (retired breeders) were recaged either alone or with other males, ANKENT developed among the grouped males only (P<0.005).
Conclusions-Caging males together is a relative risk factor for ANKENT.
Grouped caging may perturb the immune system through endocrine pathways or modify microbiological load through behaviour (for example, infection due to biting).
Mots-clés Pascal : Spondylarthropathie, Modèle animal, Rat, Rodentia, Mammalia, Vertebrata, Mâle, Facteur risque, Epidémiologie, Exposition, Sexe, Groupage, Rhumatisme inflammatoire, Système ostéoarticulaire pathologie, Rachis pathologie, Juxtaarticulaire pathologie, Enthésopathie
Mots-clés Pascal anglais : Spondylarthropathy, Animal model, Rat, Rodentia, Mammalia, Vertebrata, Male, Risk factor, Epidemiology, Exposure, Sex, Grouping, Inflammatory joint disease, Diseases of the osteoarticular system, Spine disease, Juxtaarticular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0451901
Code Inist : 002B15D. Création : 10/04/1997.