Laboratory animal workers are at high risk of developing occupational allergy.
In many cases the severity of allergy symptoms makes further work with laboratory animals impossible.
This study was designed to estimate prevalence rates of sensitization and symptoms of allergy in a population of laboratory animal workers and to determine the association between various host factors and these prevalence rates.
A cross-sectional survey was undertaken in 540 workers at eight facilities in the Netherlands.
All participants completed a questionnaire and underwent skin prick testing with common and occupational allergens.
In addition, total and specific IgE measurements were obtained.
Prevalence rates of allergy symptoms caused by working with rats and mice were 19% and 10%, respectively.
Symptoms, especially chest tightness, were strongly related to sensitization.
Rat and mouse allergy, defined as symptoms of allergy accompanied by specific atopic sensitization, were highly associated with elevated total IgE, reported adverse reactions, and positive skin prick test responses to common allergens.
This relationship could be explained by a response to can or dog allergens.
Allergy to cats or dogs seemed to be an important risk factor for laboratory animal allergy, whereas allergy to pollen or house dust mite, in the absence of can and dog allergy, appeared to be insignificant. (...)
Mots-clés Pascal : Allergie, Chat, Fissipedia, Carnivora, Mammalia, Vertebrata, Chien, Animal laboratoire, Animal, Epidémiologie, Exposition professionnelle, Facteur risque, Prévalence, Sérologie, IgE, Pays Bas, Europe, Homme, Immunopathologie, Médecine travail
Mots-clés Pascal anglais : Allergy, Cat, Fissipedia, Carnivora, Mammalia, Vertebrata, Dog, Laboratory animal, Animal, Epidemiology, Occupational exposure, Risk factor, Prevalence, Serology, IgE, Netherlands, Europe, Human, Immunopathology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0450083
Code Inist : 002B06C05. Création : 10/04/1997.