Prospective study of regular aspirin use and the risk of breast cancer.
Evidence suggests that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can inhibit tumor development in the large bowel.
An inverse association between the use of NSAIDs and the incidence of breast cancer has been observed, but this association has not been statistically significant in all studies.
We analyzed data from the prospective Nurses'Health Study to evaluate the influence of aspirin use on breast cancer risk.
We studied a population of 89 528 female registered nurses who reported no history of breast or other cancers (excluding nonmelanoma skin cancer) and who returned a mailed questionnaire in 1980 that elicited information concerning breast cancer risk factors and current and past aspirin use.
Follow-up questionnaires were mailed to the participants every 2 years ; the women were followed through 1992.
Information concerning current aspirin use was obtained from each biennial questionnaire, except in 1986.
Cases of breast cancer were identified through questionnaire responses, and permission was sought for a review of medical records to confirm the diagnoses.
Our analysis was based on 2414 cases of invasive breast cancer, which included 2303 cases confirmed with medical records and 111 cases for which no records were obtained.
Relative risks (RRs) with 95% confidence intervals (CIs), adjusted for age or age plus other known or potential breast cancer risk factors (i.e., multivariate), were calculated. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Acétylsalicylique acide, Etude cohorte, Etats Unis, Amérique du Nord, Amérique, Homme, Glande mammaire pathologie, Salicylés
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Cohort study, United States, North America, America, Human, Mammary gland diseases, Salicylates
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0449746
Code Inist : 002B20E02. Création : 10/04/1997.