It is now established that certain types of human papillomaviruses (HPVs) are the sexually transmitted agents etiologically linked to cervical cancer.
Studies assessing the contribution of the male's sexual behavior and genital HPV DNA status to the risk of development of cervical neoplasia in sexual partners have yielded inconsistent results.
This study evaluates the role of men's sexual behavior and the presence of HPV DNA in the penis on the development of cervical cancer in their sexual partners in Spain, a low-risk area for cervical neoplasia.
Husbands (n=633) of women participating in two case-control studies of cervical neoplasia were interviewed to obtain information on lifestyle habits, including sexual practices.
Cytologic samples were taken from the distal urethra and the surface of the glans penis of 183 husbands of case women and of 171 husbands of control women.
These samples were analyzed by a polymerase chain reaction-based system using a generic probe and 25 type-specific probes for the detection and typing of HPV DNA.
Serologic specimens were also obtained and analyzed for antibodies to Chlamydia trachomatis, Treponema pallidum, herpes simplex virus type II, and Neisseria gonorrhoeae.
The presence of HPV DNA in the husbands'penis conveyed a fivefold risk of cervical cancer to their wives (adjusted odds ratio [OR] for HPV DNA positivity=4.9 ; 95% confidence interval [CI]=1.9-12.6). (...)
Mots-clés Pascal : Tumeur maligne, Col utérus, Facteur risque, Epidémiologie, Comportement sexuel, Conjoint, Mâle, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, DNA, Espagne, Europe, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Risk factor, Epidemiology, Sexual behavior, Spouse, Male, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, DNA, Spain, Europe, Human, Female genital diseases, Uterine cervix diseases, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0449741
Code Inist : 002B20C02. Création : 10/04/1997.