Monitoring of aromatic amine exposures in workers at a chemical plant with a known bladder cancer excess.
In April 1991, an excess of bladder cancer cases among workers employed at a chemical manufacturing facility in Niagara Falls, NY, was reported.
This excess was primarily confined to 708 workers who had ever been employed in the rubber chemicals manufacturing area of the plant, where the aromatic amines aniline and o-toluidine have historically been used.
An environmental and biological monitoring survey was conducted to evaluate current exposures to aniline and o-toluidine in the rubber chemicals department.
Personal air sampling for aniline and o-toluidine was conducted with the use of a modified Occupational Safety and Health Administration (OSHA) 73 method.
Urine samples were collected before and after work (i.e., pre-shift and post-shift, respectively) and stored at - 70 °C. Base hydrolysis was used to convert acetanilide and N-acetyl-o-toluidine, metabolites of aniline and o-toluidine present in the urine, to the parent compounds.
The parent compounds were extracted from the alkaline urine into butyl chloride and then back-extracted from the butyl chloride into aqueous hydrochloric acid.
An aliquot of each acidic extract was subjected to ion-interaction reversed-phase liquid chromatography with coulometric electrochemical detection.
Hemoglobin (Hb) was extracted from blood and stored at - 70 °C. For the measurement of adducts of aniline, o-toluidine, and 4-aminobiphenyl (4-ABP), precipitated Hb was dissolved in 0. (...)
Mots-clés Pascal : Tumeur maligne, Vessie urinaire, Exposition professionnelle, Toluidine, Biphényl-4-ylamine, Aniline, Carcinogène, Composé aromatique, Carcinogenèse, Industrie caoutchouc, Homme, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie, Médecine travail
Mots-clés Pascal anglais : Malignant tumor, Urinary bladder, Occupational exposure, Toluidine, Biphenyl-4-ylamine, Aniline, Carcinogen, Aromatic compound, Carcinogenesis, Rubber industry, Human, Urinary system disease, Urinary tract disease, Bladder disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0449739
Code Inist : 002B14D02. Création : 10/04/1997.