Sex steroids, particularly androgens, have been implicated in the pathogenesis of prostate cancer.
Data from previous studies comparing circulating hormone levels in men with and without prostate cancer are difficult to interpret, since the studies were limited in size, hormone levels were analyzed in blood drawn after the diagnosis of cancer, nonrepresentative control subjects were used, and hormone and hormone-binding protein levels were not simultaneously adjusted.
We conducted a prospective, nested case-control study to investigate whether plasma hormone and sex hormone-binding globulin (SHBG) levels in healthy men were related to the subsequent development of prostate cancer.
Among participants in the Physicians'Health Study who provided plasma samples in 1982, we identified 222 men who developed prostate cancer by March 1992.
Three hundred ninety control subjects, matched to the case patients on the bases of age, smoking status, and length of follow-up, were also identified.
Immunoassays were used to measure the levels of total testosterone, dihydrotestosterone (DHT), 3alpha-androstanediol glucuronide (AAG), estradiol, SHBG, and prolactin in the stored (at - 82 °C) plasma samples.
Correlations between individual hormone levels and between hormone levels and SHBG in the plasma of control subjects were assessed by use of Spearman correlation coefficients (r). (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Facteur risque, Testostérone, SBP, Epidémiologie, Globuline, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Androgène, Hormone stéroïde sexuelle, Hormone testiculaire, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Prostate, Risk factor, Testosterone, Sex hormone binding protein, Epidemiology, Globulin, United States, North America, America, Human, Male genital diseases, Urinary system disease, Prostate disease, Androgen, Sex steroid hormone, Testicular hormone, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0449732
Code Inist : 002B14D02. Création : 10/04/1997.