The role of family history of lung cancer in predicting lung cancer risk among nonsmokers and their relatives was evaluated in a population-based family study conducted in metropolitan Detroit.
Lung cancer risk factor data were collected through telephone interviews with 257 nonsmoking lung cancer cases 40-84 years of age diagnosed between 1984 and 1987, their 2,252 relatives, 277 nonsmoking controls, and their 2,408 relatives.
Lung cancer in a first-degree relative was associated with a 7.2-fold (95% confidence interval 1.3-39.7) increased risk of lung cancer among nonsmokers in the 40-to 59-year-old age group.
This significant increased risk remained after adjustment for the smoking, occupational, and medical history of each family member (relative risk=6.1,95% confidence interval 1.1-33.4).
Offspring of nonsmoking cases comprised another lung cancer high risk group (relative risk=7.2,95% confidence interval 0.5-103).
A positive family history did not increase lung cancer risk among nonsmokers 60-84 years of age or their relatives.
These findings suggest that susceptibility to lung cancer in families of nonsmoking cases may be evident only in a subset of relatives of early-onset nonsmoking cases.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Epidémiologie, Homme, Etude familiale, Déterminisme génétique, Non fumeur, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Epidemiology, Human, Family study, Genetic inheritance, Non smoker, United States, North America, America, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0441392
Code Inist : 002B11A. Création : 10/04/1997.