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  1. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study.

    Article - En anglais

    Background 

    Evidence suggests that pathophysiologic processes in bone are important determinants of outcome in osteoarthritis of the knee.

    Low intake and low serum levels of vitamin D may compromise favorable responses of bone to osteoarthritis, predisposing patients to progression.

    Objective 

    To determine whether dietary intake and serum levels of vitamin D would predict the incidence and progression of osteoarthritis of the knee in participants of the Framingham Study.

    Design 

    Prospective observational study.

    Setting 

    The Framingham Study.

    Participants 

    Participants in the Framingham Heart Study who had knee radiography at examinations 18 (done between 1983 and 1985) and 22 (done between 1992 and 1993) and received interim assessments of vitamin D intake and serum levels.

    Measurements 

    Intake of vitamin D and serum levels of 25-hydroxyvitamin D, calculated on the basis of dietary habits and supplement use as reported on a questionnaire, were evaluated at examination 20 (1988 to 1989).

    Knee radiographs were given scores for global severity of osteoarthritis, using a modification of the scale of Kellgren and Lawrence (range, 0 to 4), and for the presence of osteophytes and joint-space narrowing (range, 0 to 3).

    Covariates measured at examinations 18 and 20 were age, sex, body mass index, weight change, injury, physical activity, health status, bone mineral density, and energy intake.

    Results 

    556 participants (mean age at baseline ± SD, 70.3 ± 4. (...)

    Mots-clés Pascal : Arthrite, Articulation, Genou, Régime alimentaire, Vitamine D, Physiopathologie, Facteur risque, Epidémiologie, Homme, Etats Unis, Amérique du Nord, Amérique, Membre inférieur, Système ostéoarticulaire pathologie, Arthropathie

    Mots-clés Pascal anglais : Arthritis, Joint, Knee, Diet, Vitamin D, Pathophysiology, Risk factor, Epidemiology, Human, United States, North America, America, Lower limb, Diseases of the osteoarticular system, Arthropathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0440202

    Code Inist : 002B15G. Création : 10/04/1997.