Objectives The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances.
The partition coefficients between blood and air and adipose tissue and air were determined for widely used aromatic solvents in an in vitro test system using human tissue samples.
Methods Samples of whole venous blood (N=35) were drawn from 10 subjects.
In addition, samples of perirenal and epididymal adipose tissue were obtained from F344 rats, along with subcutaneous, omental, or inguinal adipose tissue from 43 patients who had undergone surgery.
Portions of each tissue were injected into vials for equilibration with atmospheres containing deuterated and nondeuterated organic solvents.
Gas chromatographic headspace analysis was then used to determine the partition coefficients between blood and air and adipose tissue and air.
Results The mean partition coefficients between human blood and air or adipose tissue and air were 334 (SE 11) (adipose tissue) for benzene ; 1764 (SE 49) (adipose tissue) for ethylbenzene ; 3184 (SE 84) (adipose tissue) for styrene ; 18.3 (SE 0.24) (blood) and 962 (SE 32) (adipose tissue) for toluene ; 35.2 (SE 0.45) (blood) and 2460 (SE 63) (adipose tissue) for o-xylene ; 31.9 (SE 0.45) (blood) and 1919 (SE 53) (adipose tissue) for m-xylene ; and 39.0 (SE 0.70) (blood) and 2019 (SE 102) forp-xylene.
Regression analyses revealed coefficients of determination of 0. (...)
Mots-clés Pascal : Benzène, Styrène, Toluène, Xylène, Toxicocinétique, Distribution, Coefficient partage, Sang, Air, Tissu adipeux, Médecine travail, Analyse quantitative, Homme, In vitro, Solvant organique
Mots-clés Pascal anglais : Benzene, Styrene, Toluene, Xylene, Toxicokinetics, Distribution, Partition coefficient, Blood, Air, Adipose tissue, Occupational medicine, Quantitative analysis, Human, In vitro, Organic solvent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0439012
Code Inist : 002B03L04. Création : 10/04/1997.