A thirteen-year follow-up of respiratory effects of acute exposure to sulfur dioxide.
Objectives In 1977, nine men were accidentally exposed to sulfur dioxide in an explosion in a pyrite mine.
The lung function of seven men was followed after the accident.
A four-year follow-up has been published previously.
The greatest decrease in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1.0), and maximal midexpiratory flow (MMEF) was observed one week after the accident, after which all these parameters improved without reaching the preaccident level.
Reversible bronchial obstruction was still present in three patients, and a positive reaction in the histamine challenge test was found for four.
In the present paper, the lung function follow-up 13 years after the accident is reported for six men.
Methods The patients'clinical condition, chest X-ray, spirometry, and histamine challenge test were studied 13 years after the incident.
Results Spirometry was normal in one worker, two displayed obstruction, and three had a combined obstructive and restrictive, mainly obstructive, ventilatory impairment.
In the histamine challenge test, four patients showed bronchial hyperreactivity, one with a nearly significant reaction.
Because of bronchial obstruction one patient could not perform the challenge test.
Conclusions This 13-year follow-up showed that acute inflammatory obstruction caused by exposure to sulfur dioxide left, as sequelae, obstructive impairment of ventilatory function and permanent bronchial hyperreactivity. (...)
Mots-clés Pascal : Pyrite, Explosion, Mine, Accident, Toxicité, Soufre dioxyde, Intoxication, Surveillance, Fonction respiratoire, Bronchopneumopathie obstructive, Médecine travail, Complication, Evolution, Séquelle, Homme, Accident travail, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Pyrite, Explosions, Mine, Accident, Toxicity, Sulfur dioxide, Poisoning, Surveillance, Lung function, Obstructive pulmonary disease, Occupational medicine, Complication, Evolution, Sequela, Human, Occupational accident, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0438891
Code Inist : 002B03L02. Création : 10/04/1997.