Objectives The purpose of the study was to determine whether paternal occupational exposure to dioxin-contaminated chlorophenols is associated with an increased risk of congenital anomalies or other adverse reproductive outcomes in offspring.
Methods As a result of a multistep linkage, 19 675 births between 1952 and 1988 were identified as children of a cohort of 9512 fathers who had worked at least one year in British Columbia sawmills where chlorophenate wood preservatives had been used.
A nested case-referent analysis was applied, using conditional logistic regression, with five referents matched per case according to year of birth and gender.
Chlorophenate exposure was based on expert raters'estimations of hours of exposure applied to specific time windows prior to birth.
Results The offspring of male sawmill workers were at increased risk for developing congenital anomalies of the eye, particularly congenital cataracts ; elevated risks for developing anencephaly or spina bifida and congenital anomalies of genital organs were shown according to specific windows of exposure.
No associations were found for low birthweight, prematurity, stillbirths, or neonatal deaths.
Conclusions The study adds further support to the hypothesis of male-mediated developmental toxicity.
Paternal exposure to chlorophenates was associated with the development of certain congenital anomalies in offspring.
Mots-clés Pascal : Exposition professionnelle, Dioxine dérivé, Père, Reproduction, Phénol(perchloro), Maladie congénitale, Prématurité, Poids naissance faible, Mort né, Tératogène, Scierie, Médecine travail, Facteur risque, Epidémiologie, Toxicité, Foetus, Nouveau né, Homme, Colombie britannique, Canada, Amérique du Nord, Amérique, Foetus pathologie, Nouveau né pathologie, Phénol(tétrachloro), Pentachlorophenol
Mots-clés Pascal anglais : Occupational exposure, Dioxin derivatives, Father, Reproduction, Pentachlorophenol, Congenital disease, Prematurity, Low birth weight, Stillborn, Teratogen, Saw mill, Occupational medicine, Risk factor, Epidemiology, Toxicity, Fetus, Newborn, Human, British Columbia, Canada, North America, America, Fetal diseases, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0438357
Code Inist : 002B03G. Création : 10/04/1997.