Occupation and risk of germ cell testicular cancer by histologic type in Ontario.
Incidence of both major histologic subgroups of germ cell testicular cancer, seminoma and nonseminoma, is increasing but the etiology is largely unknown.
Occupational clusters have been observed.
In a case-control study in Ontario with 495 incident cases and 974 population control subjects, jobs and industries were coded and analyzed.
There is little evidence of occupational risk for all cases or for seminoma.
Significantly increased risk of nonseminoma was associated with : miners (odds ratio [OR]=12.39 ; 95% confidence interval [CI], 2.22 to 69.27), food and beverage processors (OR=3.20 ; 95% CI, 1.39 to 7.35), utilities employees (OR=3.15 ; 95% CI, 1.15 to 8.61), and other service workers (OR=1.05 ; 95% CI, 1.05 to 4.56).
Leather-industry employees had elevated risk of nonseminoma (OR=4.60 ; 95% CI, 0. 75 to 28. 28) consistent with a leather tannery cluster.
Increased risk of nonseminoma among some workers can be explained if an additional event is required for converting seminoma to nonseminoma.
Mots-clés Pascal : Homme, Exposition professionnelle, Médecine travail, Tumeur germinale, Tumeur maligne, Testicule, Facteur risque, Epidémiologie, Ontario, Canada, Amérique du Nord, Amérique, Etiologie, Type histologique, Séminome, Appareil génital mâle pathologie, Testicule pathologie, Etude cas témoin
Mots-clés Pascal anglais : Human, Occupational exposure, Occupational medicine, Germ cell tumor, Malignant tumor, Testicle, Risk factor, Epidemiology, Ontario, Canada, North America, America, Etiology, Histological type, Seminoma, Male genital diseases, Testicular diseases, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0436173
Code Inist : 002B20B02. Création : 10/04/1997.