MEDICHEM Congress on Occupational and Environmental Health in the Chemical Industry. Cambridge, Massachusetts USA, 1995/09/19.
Adducts with the N-terminal valine of erythrocyte globin can serve as individual biomarkers of systemic and cellular exposure to endogenous and exogenous alkylating agents.
In contrast to « detoxification markers » of this kind of mecapturic acids derived from alkylation of glutathione, individual N-alkylations of valine in globin reflect the formally « toxifying » part of the stress due to alkylating agents transformed into the ultimate toxicant.
Thus, in contrast to the traditional methods of biological monitoring this approach enables a better evaluation of systemic exposure to reactive agents, adapted more sensibly to the exposure situation over the whole life span of erythrocytes, and it can serve as a specific biomarker of exposure for the purpose of health surveillance in occupational medicine.
An individual evaluation of exposures in comparison with the range of corresponding background levels is discussed from the point of view of supplementary risk assessment in medical surveillance of occupationally exposed persons.
Mots-clés Pascal : Carcinogène, Agent alkylant, Exposition professionnelle, Surveillance biologique, Adduit moléculaire, Valine, Globine, Erythrocyte, Marqueur biologique, Acrylonitrile, Homme, Médecine travail, Aminoacide
Mots-clés Pascal anglais : Carcinogen, Alkylating agent, Occupational exposure, Biological monitoring, Molecular adduct, Valine, Globin, Red blood cell, Biological marker, Acrylonitrile, Human, Occupational medicine, Aminoacid
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0435630
Code Inist : 002B04E02. Création : 10/04/1997.