Is there a relationship between the use of analgesics and non-steroidal anti-inflammatory drugs and acute upper gastrointestinal bleeding : A finnish case-control prospective study.
Our object was to study the role of non-steroidal anti-inflammatory drugs (NSAIDs) as a risk factor in upper gastrointestinal bleeding.
Forty-eight patients with acute bleeding due to esophagitis, gastric or duodenal ulcer, or erosions and 156 age-and sex-matched control patients from the same emergency units were interviewed about the history of ulcer disease, smoking and alcohol habits, and use of analgesics or NSAIDs.
Twenty-four patients (50%) and 90 controls (57.6%) had no previous upper abdominal symptoms (NS).
There were more heavy smokers among patients (n=9 ; 18.8%) than controls (n=7 ; 4.5%) (p<0.01).
Five patients (10.4%) and one control (0.6%) had taken more than 20 drinks during the week before admission (p<0.001).
Twenty-nine patients (62.5%) and 81 controls (51.9%) had used some analgesics during the week before admission (NS).
There was no difference in the duration of the use of analgesics in the patients and controls.
The results do not support the concept that NSAIDs are a major factor associated with serious upper gastrointestinal bleeding.
Mots-clés Pascal : Hémorragie, Gastrointestinal, Aigu, Relation, Chimiothérapie, Analgésique, Antiinflammatoire non stéroïde, Facteur risque, Etude statistique, Homme, Finlande, Europe, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Pharmacovigilance, Toxicologie
Mots-clés Pascal anglais : Hemorrhage, Gastrointestinal, Acute, Relation, Chemotherapy, Analgesic, Non steroidal antiinflammatory agent, Risk factor, Statistical study, Human, Finland, Europe, Digestive diseases, Gastric disease, Intestinal disease, Cardiovascular disease, Vascular disease, Pharmacovigilance, Toxicology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0432762
Code Inist : 002B12B03. Création : 10/04/1997.