Helicobacter pylori, non-steroidal anti-inflammatory drugs, family history, blood group O, hyperpepsinogenaemia A, alcohol and smoking have been reported to be risk factors for peptic ulcer disease.
The strength of causal risk factors may differ in different populations.
In 215 Japanese and 493 Dutch employees of similar age, gender and type of occupation, a structured history was obtained using a questionnaire and fasting serum samples were analysed for IgG antibodies to H. pylori and pepsinogen A all in the same laboratory.
A past ulcer history was verified through case notes.
We found that H. pylori seropositivity, a high serum pepsinogen A and a family history of ulcer disease were significant and independent risk factors for peptic ulcer disease.
For H. pylori seropositivity there was a 20-fold increased risk among the Dutch and an eight-fold increased risk among the Japanese.
The seroprevalence of H. pylori was 90% in 20 Dutch subjects with a verified ulcer history and 95% in 41 Japanese ulcer subjects ; it was 29% in Dutch non-ulcer subjects and 70% in Japanese non-ulcer subjects.
The cumulative difference in risk to develop peptic ulcer disease at the age of 48 years between H. pylori-infected and - uninfected subjects was 24.5-3.0=21.5% for the Japanese and 11.8-0.5=11.3% for the Dutch.
Duodenal ulcer disease was associated with a high coffee consumption only among the Japanese population, where this habit was much less prevalent than among the Dutch. (...)
Mots-clés Pascal : Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Ulcère, Gastroduodénal, Facteur risque, Epidémiologie, Homme, Japonais, Néerlandais, Bactériose, Infection, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie
Mots-clés Pascal anglais : Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Ulcer, Gastroduodenal, Risk factor, Epidemiology, Human, Japanese, Dutch, Bacteriosis, Infection, Digestive diseases, Gastric disease, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0431985
Code Inist : 002B13B03. Création : 10/04/1997.