This review of published data on the epidemiology, pathology, and molecular biology of breast cancer in African American women seeks to identify how the etiology and presentation of the disease differ from those in white women.
The crossover from higher to lower age-specific incidence rates in African American women at age 45 cannot be explained by current data on the distribution of risk factors.
Data from six case-control studies suggest that the relative risks associated with both established and probable breast cancer risk factors are similar in African American and white women.
Lower survival in African American compared to white women is primarily attributable to diagnosis at a later stage.
However, evidence from a number of studies suggests that tumors in African American women may exhibit a more aggressive phenotype, which could also contribute to the survival disparity.
Tumors in African American women are more likely to occur at a younger age, to be poorly differentiated and estrogen receptor negative, and to exhibit high grade nuclear atypia, more aggressive histology (more medullary and less lobular), and higher S-phase.
Overexpression of p53 and erbB-2 occurs with similar frequency in African American and white women, although limited data suggest the former may exhibit different p53 mutation spectra.
One study found high risk associated with a specific CYP1A1 polymorphism in African American but not white women. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Ethnie, Négroïde, Caucasoïde, Etude comparative, Etats Unis, Amérique du Nord, Amérique, Homme, Article synthèse, Femelle, Pathogénie, Epidémiologie, Etiologie, Physiopathologie, Facteur risque, Gène suppresseur tumeur, Gène onc cellulaire, Cytochrome P450, Récepteur hormonal, Oestrogène, Génétique, Prédisposition, Progestérone, Glande mammaire pathologie, Survie, Cytochrome CYP1A1, Gène erbB-2, Gène p53
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Ethnic group, Negroid, Caucasoid, Comparative study, United States, North America, America, Human, Review, Female, Pathogenesis, Epidemiology, Etiology, Pathophysiology, Risk factor, Tumor suppressor gene, C-Onc gene, Cytochrome P450, Hormonal receptor, Estrogen, Genetics, Predisposition, Progesterone, Mammary gland diseases, Survival, p53 gene
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0429263
Code Inist : 002B20E02. Création : 10/04/1997.