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  1. Lobular neoplasia : Long term risk of breast cancer and relation to other factors.

    Article - En anglais

    BACKGROUND

    Lobular neoplasia (LN), also known as lobular carcinoma in situ, is an incidental histologic finding in tissue removed at breast surgery.

    Patients with LN are known to be predisposed to develop invasive or intraductal carcinoma (CA).

    This study investigates factors that influence the cancer risk in LN patients.

    METHODS

    Analysis of data concerning long term follow-up (median : 18 yrs) of 236 patients with LN identified in a pathologic review of more than 2000 biopsy specimens with benign epithelial proliferative breast disease.

    RESULTS

    The probability of CA developing in either breast in long term survivors after a biopsy that contained LN was approximately 1/3, which is 5.4 times (95% CI : 4.2-7.0) the rate in the general population.

    The relative risk (RR) tended to decrease with increasing age at diagnosis, but was approximately doubled (RR : 1.8 ; 95% CI : 1.1-3.2) for patients with benign epithelial breast disease preceding their initial diagnosis of LN.

    CA risk remained markedly elevated for at least 20 years, and increased substantially if there was a second operation showing LN-from 4.9 (95% CI : 3.7-6.4) after a single operation with LN to 16.1 (95% CI : 6.9-31.8) after a second such operation.

    CONCLUSIONS

    LN is a marker of increased CA risk that is further exacerbated by episodes of preexisting benign breast epithelial proliferative changes, and that remains substantially elevated for many years.

    Mots-clés Pascal : Adénocarcinome lobulaire, Glande mammaire, In situ, Homme, Facteur risque, Evolutivité, Grade histologique, Epidémiologie, Tumeur maligne, Glande mammaire pathologie, Anatomopathologie

    Mots-clés Pascal anglais : Lobular adenocarcinoma, Mammary gland, In situ, Human, Risk factor, Evolutivity, Histological grading, Epidemiology, Malignant tumor, Mammary gland diseases, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0429017

    Code Inist : 002B20E02. Création : 10/04/1997.