Attempts were made to clarify the correlation between human T-cell leukemia/lymphoma virus (HTLV) - 1 infection and malignant oncogenicity other than adult T-cell leukemia/lymphoma (ATL) in a case-control study.
The occurrence of primary malignant neoplasms (MN) in 110 ATL patients, their parents, and 430 siblings was compared with HTLV-I seronegative non-Hodgkin's lymphoma (NHL) patients, their parents, and 867 siblings.
The chi-square test, odds ratio (OR), and 95% confidence intervals (CI) were used to determine the statistical significance of differences in the occurrence of the primary MN among ATL patients, HTLV-I seronegative NHL patients, their siblings, and their parents.
The occurrence of primary MN in the ATL patients was higher than the occurrence in HTLV-1 seronegative NHL patients (P=0.0036 ; OR=2.91 ; 95% CI : 1.42,6.02).
In siblings of the ATL patients, there was a higher occurrence of primary MN than in siblings of the HTLV-1 seronegative NHL patients (P<0.0001 ; OR=3.35 ; 95% CI : 2.01,5.58).
In mothers of the ATL patients, there was a higher occurrence of primary MN than in mothers of the HTLV-I seronegative NHL patients (P=0.0063 ; OR=2.55 ; 95% CI : 1.30,5.00), but not in fathers (P=0.1602 ; OR=1.68 ; 95% CI : 0.81,3.47).
There is an increased risk of primary MN in ATL patients, their siblings, and their mothers.
Mots-clés Pascal : Lymphome, Leucémie cellule T adulte, Virose, Infection, Homme, Facteur risque, Tumeur maligne, Etude familiale, Epidémiologie, Japon, Asie, Parent, Fratrie, Etude comparative, Lymphome non hodgkinien, Virus HTLV1, Retroviridae, Virus, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Lymphoma, Adult T cell leukemia, Viral disease, Infection, Human, Risk factor, Malignant tumor, Family study, Epidemiology, Japan, Asia, Parent, Sibling, Comparative study, Non Hodgkin lymphoma, HTLV-I virus, Retroviridae, Virus, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0427764
Code Inist : 002B19B. Création : 10/04/1997.