Efficacy of a surveillance program for early detection of hepatocellular carcinoma.
Contrasting data have so far been reported on the utility and efficacy of screening patients with cirrhosis for early detection of hepatocellular carcinoma (HCC).
The goal of this study was to evaluate the efficacy of a regular ultrasonographic and laboratory follow-up for the early detection of small HCC, and to identify parameters correlated with a higher risk of developing HCC.
One hundred and sixty-four consecutive patients with liver cirrhosis living in Emilia Romagna, Italy, were enrolled in the period 1989-1991.
All patients underwent clinical, biochemical, and ultrasonographic evaluations at entry and at 3-and 6-month intervals during follow-up.
By April 1995,34 patients had developed HCC.
In 76% of the patients, ultrasonography identified HCC when it was still single and small (<4 cm).
At discriminant, logistic regression and univariate analyses, sex and the entry concentration of alkaline phosphatase, alpha-fetoprotein, gamma-glutamyl transpeptidase, and albumin were associated with a higher risk of developing HCC, whereas at multivariate analysis (Cox's model), only sex and the entry concentration of alkaline phosphatase, albumin, and alpha-fetoprotein were independently and significantly related to the appearance of HCC.
Mots-clés Pascal : Carcinome hépatocellulaire, Homme, Dépistage, Echographie, Incidence, Facteur risque, Cirrhose, Marqueur biologique, Surveillance, Italie, Europe, Pronostic, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Exploration ultrason
Mots-clés Pascal anglais : Liver cell carcinoma, Human, Medical screening, Echography, Incidence, Risk factor, Cirrhosis, Biological marker, Surveillance, Italy, Europe, Prognosis, Digestive diseases, Hepatic disease, Malignant tumor, Sonography
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0427753
Code Inist : 002B13C01. Création : 10/04/1997.