Between April 1988 and December 1992,37 patients with small, previously unirradiated, primary non-small cell carcinomas of the bronchus causing symptoms due to endobronchial disease were treated at the Christie Hospital, Manchester, with a single fraction of high dose rate intraluminal radiotherapy (ILT) using the microSelectron-HDR machine.
Small primary (SP) lesions were defined as being less than 2 cm in diameter in a direction perpendicular to the central axis of the iridium-192 treatment source.
Fifteen patients (41%) were treated to a dose of 15 Gy and 22 patients (59%) to 20 Gy at a distance of 1 cm from the central axis of the source.
At 6 weeks following ILT, improvement in symptoms was seen in the following percentages of patients : haemoptysis 96%, pulmonary collapse 69%, cough 55% and dyspnoea 52%. The magnitude of improvement in these symptoms was largely maintained in patients surviving to 4 months and then 12 months post-ILT.
Median actuarial survival was 709 days, 2-year survival 49.4% and 5-year survival 14.1%. Overall, there was no significant difference in survival after treatment with 20 Gy compared with 15 Gy at 1 cm.
At the close of study, there were four patients still alive without disease recurrence with survivals of 38,48,49 and 63 months.
All had had biopsy-proven squamous cell carcinomas and all had been treated with 20 Gy at 1 cm. (...)
Mots-clés Pascal : Carcinome non petite cellule, Bronchopulmonaire, Homme, Efficacité traitement, Curiethérapie, Intraluminal, Dose forte, Morbidité, Symptomatologie, Survie, Long terme, Epidémiologie, Etude comparative, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne, Radiothérapie
Mots-clés Pascal anglais : Non small cell carcinoma, Bronchopulmonary, Human, Treatment efficiency, Curietherapy, Intraluminal, High dose, Morbidity, Symptomatology, Survival, Long term, Epidemiology, Comparative study, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor, Radiotherapy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0426700
Code Inist : 002B11A. Création : 10/04/1997.