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  1. Tobacco smoking and alcohol consumption as risk factors for glioma : a case-control study in Melbourne, Australia.

    Article - En anglais

    Objective

    To investigate possible associations between tobacco smoking and alcohol consumption and the risk of adult glioma.

    Design

    This was a population based, case-control study.

    Relative risks (RR) were estimated using logistic regression analysis.

    Setting

    Melbourne, Australia.

    Participants

    These comprised 416 case subjects (166 women, 250 men), 66% of those eligible ; and 422 control subjects (170 women, 252 men), 43.5% of those potentially eligible.

    Results

    There was no increase in risk of glioma with having ever smoked tobacco (RR 1.29,95% CI 0.95,1.75) for all subjects, adjusted for age, a reference date, and gender.

    There was a slight increase in risk for men (RR 1.64,95% CI 1.1,2.45), but not for women (RR 0.99,95% CI 0.62,1.62).

    For men, there was no increase in risk with increasing pack-years of cigarette smoking, but the risk was significantly increased in subjects who had smoked for less than 10 years.

    There was no increase in risk associated with having ever drunk alcohol for all subjects (RR 0.96,95% CI 0.67,1.37), women (RR 0.69,95% CI 0.4,1.15) or men (RR 1.40,95% CI 0.81,2.43).

    Conclusions

    This study does not support an association between either tobacco smoking or alcohol consumption and glioma.

    The pattern of risk associated with tobacco smoking in men appears inconsistent with a causal role, and may be due to chance, response bias, or uncontrolled confounding.

    Mots-clés Pascal : Gliome, Tabagisme, Consommation, Ethanol, Boisson alcoolisée, Etude en condition contrôlée, Facteur risque, Adulte, Homme, Epidémiologie, Australie, Océanie, Système nerveux pathologie, Système nerveux central pathologie, Tumeur

    Mots-clés Pascal anglais : Glioma, Tobacco smoking, Consumption, Ethanol, Alcoholic beverage, Controlled environment study, Risk factor, Adult, Human, Epidemiology, Australia, Oceania, Nervous system diseases, Central nervous system disease, Tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0425890

    Code Inist : 002B17E. Création : 10/04/1997.