Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder.
We describe the prevalence of metabolic risk factors for CVD in a young working population and the tendency for individuals with some risk factors to acquire additional factors.
This was a retrospective three-year follow-up study of baseline CVD risk factors assessing (1) incidence of risk factors and (2) fatal CVD.
The study group consisted of 9,747 Eastman Kodak employees, who participated in a worksite-based cardiovascular screening program in Rochester, New York, which included a medical history, physical examination, and laboratory evaluation.
Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl) ; (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women ; or low-density lipoproteins of 160 or greater ; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg ; or diastolic above 90 mmHg).
Subjects were classified as having none, one, two, or all three risk factors.
Prevalence of single risk factors were : hypertension 9.8%, abnormal lipids 22.6%, and abnormal glucose 1.5%. Combinations of two risk factors were greater than expected by chance (p<0.01).
Individuals who started with one or more abnormal values tended to have an increased risk of developing others. (...)
Mots-clés Pascal : Appareil circulatoire pathologie, Hypertension artérielle, Hyperglycémie, Glucose, Hyperlipémie, Lipide, Facteur risque, Trouble métabolisme, Homme, Etude cohorte, Rétrospective, Métabolisme pathologie
Mots-clés Pascal anglais : Cardiovascular disease, Hypertension, Hyperglycemia, Glucose, Hyperlipemia, Lipids, Risk factor, Metabolic disorder, Human, Cohort study, Retrospective, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0420261
Code Inist : 002B12B06. Création : 10/04/1997.