Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan.
To investigate the carcinogenic effect of environmental aflatoxin exposure, 56 cases of hepatocellular carcinoma (HCC) diagnosed between 1991 and 1995 were identified and individually matched by age, sex, residence and date of recruitment to 220 healthy controls from the same large cohort in Taiwan.
Blood samples were analyzed for hepatitis B and C viral markers and for aflatoxin-albumin adducts ; urine was tested for aflatoxin metabolites.
We obtained information about sociodemographic characteristics, habitual alcohol drinking, cigarette smoking and diet in a structured interview.
Hepatitis B virus surface antigen (HBsAg) carriers had a significantly increased risk for HCC.
After adjustment for HBsAg serostatus, the matched odds ratio (ORm) was significantly elevated for subjects with high levels of urinary aflatoxin metabolites.
When stratified into tertiles, a dose-response relationship with HCC was observed.
The ORm for detectable aflatoxin-albumin adducts was not significant after adjustment for HBsAg serostatus.
HBsAg-seropositive subjects with high aflatoxin exposure had a higher risk than subjects with high aflatoxin exposure only or HBsAg seropositivity only.
In male HBsAg-seropositive subjects, adjusted ORs were 2.8 (95% confidence interval [CI]=0.9-9.1) for detectable compared with non-detectable aflatoxin-albumin adducts and 5.5 (Cl=1.3-23.4) for high compared with low urinary aflatoxin metabolite levels. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Facteur risque, Epidémiologie, Aflatoxine, Carcinogène, Taiwan, Asie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Liver cell carcinoma, Risk factor, Epidemiology, Aflatoxin, Carcinogen, Taiwan, Asia, Human, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0418769
Code Inist : 002B13C01. Création : 10/04/1997.