Susceptibility to human papillomavirus-associated cervical intra-epithelial neoplasia is determined by specific HLA DR-DQ alleles.
Human papillomaviruses (HPV) play a causative role in the aetiology of cervical intra-epithelial neoplasia (CIN) and cervical cancer.
Human leukocyte antigens (HLA) are important in the regulation of immune response to foreign antigens.
The role of genetic variation at the HLA class II loci (DR and DQ) in CIN (HPV 16,18,31 and 33 typed) was investigated by PCR DNA amplification and oligonucleotide probe typing of cervical smears from British Caucasian patients (n=176) and controls (n=416).
The alleles of the DQBI*03, DRBI*04 and DRBI*II loci were strongly associated with susceptibility to CIN.
Specifically, the haplotypes DRBI*0401-DQBI*0301 and DRBI*I 101*DQB1*0301 were significant and indicated susceptibility.
The DQB1*03 locus was more contributory to this association than the DRB I loci.
A weak protective effect was shown for the haplotype DRB1*0101-DQB1*0501.
Positive correlation was also observed for HPV-positive CIN, suggesting that specific HLA class II alleles may be important in determining the immune response to HPV antigens and the risk for CIN after HPV infection.
Our results should help in the rational design of vaccines against HPV.
Mots-clés Pascal : Dysplasie col utérus, Facteur risque, Epidémiologie, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Variabilité génétique, Locus HLA-DQ, Locus HLA-DR, Système HLA, Système histocompatibilité majeur, Réponse immune, Angleterre, Grande Bretagne, Royaume Uni, Europe, Homme, Lésion précancéreuse, Col utérus, Appareil génital femelle pathologie, Col utérus pathologie
Mots-clés Pascal anglais : Cervical dysplasia, Risk factor, Epidemiology, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Genetic variability, HLA-DQ-Locus, HLA-DR-Locus, HLA-System, Major histocompatibility system, Immune response, England, Great Britain, United Kingdom, Europe, Human, Premalignant lesion, Uterine cervix, Female genital diseases, Uterine cervix diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0418767
Code Inist : 002B20C02. Création : 10/04/1997.