An apparent lack of association between Helicobacter pylori infection and risk of gastric cancer in China.
Several prospective studies have shown a significant association between Helicobacter pylori seropositivity and the risk of gastric cancer.
Only a small proportion of H. pylori-infected individuals will, however, develop gastric cancer, and it is unclear what effects other factors, such as diet, might have on the risk of cancer.
Eighty-seven subjects with gastric cancer were identified during the first 6 years of follow-up (mean 2.4 years) of a cohort of middle-aged men from Shanghai, China.
They were matched with 261 cancer-free controls, and serum samples from all subjects, obtained at recruitment, were assayed for anti-H. pylori IgG antibodies.
Questionnaire data provided information on a wide range of socio-demographic life-style and dietary variables.
H. pylori seropositivity rates in the cases and controls were 54% and 56%, respectively.
Neither the overall risk of developing gastric cancer nor the risk of developing non-cardia gastric cancer was significantly associated with prior H. pylori seropositivity.
Adjustment for any of the other medical, dietary or life-style variables studied had little effect on the risk of developing non-cardia gastric cancer ; simultaneous adjustment for all of these factors yielded an odds ratio of 1.17.
The results do not support the hypothesis that H. pylori plays a role in the process of gastric carcinogenesis in China.
It is possible that this is an artefact resulting from the relatively short follow-up period to date.
Mots-clés Pascal : Tumeur maligne, Estomac, Facteur risque, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Epidémiologie, Etude cohorte, Chine, Asie, Homme, Appareil digestif pathologie, Estomac pathologie
Mots-clés Pascal anglais : Malignant tumor, Stomach, Risk factor, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Epidemiology, Cohort study, China, Asia, Human, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0417870
Code Inist : 002B13B01. Création : 10/04/1997.