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  1. An apparent lack of association between Helicobacter pylori infection and risk of gastric cancer in China.

    Article - En anglais

    Several prospective studies have shown a significant association between Helicobacter pylori seropositivity and the risk of gastric cancer.

    Only a small proportion of H. pylori-infected individuals will, however, develop gastric cancer, and it is unclear what effects other factors, such as diet, might have on the risk of cancer.

    Eighty-seven subjects with gastric cancer were identified during the first 6 years of follow-up (mean 2.4 years) of a cohort of middle-aged men from Shanghai, China.

    They were matched with 261 cancer-free controls, and serum samples from all subjects, obtained at recruitment, were assayed for anti-H. pylori IgG antibodies.

    Questionnaire data provided information on a wide range of socio-demographic life-style and dietary variables.

    H. pylori seropositivity rates in the cases and controls were 54% and 56%, respectively.

    Neither the overall risk of developing gastric cancer nor the risk of developing non-cardia gastric cancer was significantly associated with prior H. pylori seropositivity.

    Adjustment for any of the other medical, dietary or life-style variables studied had little effect on the risk of developing non-cardia gastric cancer ; simultaneous adjustment for all of these factors yielded an odds ratio of 1.17.

    The results do not support the hypothesis that H. pylori plays a role in the process of gastric carcinogenesis in China.

    It is possible that this is an artefact resulting from the relatively short follow-up period to date.

    Mots-clés Pascal : Tumeur maligne, Estomac, Facteur risque, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Epidémiologie, Etude cohorte, Chine, Asie, Homme, Appareil digestif pathologie, Estomac pathologie

    Mots-clés Pascal anglais : Malignant tumor, Stomach, Risk factor, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Epidemiology, Cohort study, China, Asia, Human, Digestive diseases, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0417870

    Code Inist : 002B13B01. Création : 10/04/1997.