Adjustment of creatinine-adjusted value to urine flow rate in lead workers. Commentary.
Two male lead workers, aged 57 and 51 y, were studied to compare the urinary flow/creatinine-adjusted values published earlier by Araki et at. and by Greenberg and Levine.
We collected 24-h urine samples once a month for 31 mo and 16 mo for workers 1 and 2, respectively.
The workers'urinary excretions of lead, delta-aminolevulinic acid, and coproporphyrin were measured.
No significant correlations between urine flow rate and urinary flow/creatinine-adjusted values published by Araki et at. for the three substances were found for these two workers.
However, urinary flow/creatinine-adjusted values presented by Greenberg and Levine for lead and delta-aminolevulinic acid were correlated positively with urine flow rate in the two workers, and their adjusted value for coproporphyrin was correlated positively with urine flow rate in one of the workers.
We concluded that use of the urinary flow/creatinine-adjusted value by Greenberg and Levine for biological monitoring poses a problem because of the theoretical fallacy.
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Médecine travail, Homme, Débit, Urine, Créatinine, Surveillance biologique, Méthode étude, Liquide biologique
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Occupational medicine, Human, Flow rate, Urine, Creatinine, Biological monitoring, Investigation method, Biological fluid
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0416993
Code Inist : 002B03L05. Création : 10/04/1997.