The effect of lead exposure on blood pressure in the modern industrial setting is controversial.
In this study, we followed 67 workers in a lead-battery plant for 6-10 y, and blood pressure and blood lead levels were measured every 6 mo.
Weight, height, alcohol intake, cigarette smoking, and age were recorded.
Partial correlation coefficients showed that initial systolic blood pressure, age, and body mass index (i.e., weight/height squared) accounted for 25%, 30.9%, and 20.2%, respectively, of the variance in systolic blood pressure (p<. 001 in all cases).
Conversely, average blood lead levels (13<3 tests/worker) accounted for only 0.4% of the variance (not significant).
Repeated-measures analysis of variance showed a small-but significant-association between blood lead levels and systolic blood pressure.
There was a negative correlation between blood lead levels and diastolic blood pressure.
There were 18 men with average blood lead levels that were less than 30 mug/dl (average=25 ± 3 mug/dl), and 32 men had levels of 40 mug/dl or more (average=47 ± 6 mug/dl).
The mean final systolic blood pressure, adjusted for age, and initial systolic blood pressure were 117 7 ± 13 mm Hg and 114 ± 11 mm Hg, respectively.
We concluded that blood lead levels had no clinically significant effect on blood pressure in lead-battery workers.
The main predictors of the follow-up systolic blood pressure were age, body mass index, and initial systolic blood-pressure measurements.
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Industrie, Homme, Médecine travail, Etude longitudinale, Pression sanguine, Epidémiologie
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Industry, Human, Occupational medicine, Follow up study, Blood pressure, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0416992
Code Inist : 002B03L05. Création : 10/04/1997.