Acute effects of exposure to air contaminants in a sawmill on healthy volunteers.
To study whether air contaminants in sawmills can induce acute changes in the upper and lower airways of previously non-exposed subjects.
Method-Nineteen healthy volunteers were examined to find the concentration of interleukin 6 (IL-6) in nasal lavage fluid and lung function before and after five hour exposure to dusts and fumes generated in a sawmill where timber from Scots pine was sawed.
When exposed, the subjects had respirators with and without a particle filter.
The median for daily time weighted average concentration of total dust for subjects with respirators without a filter was 0.13 mg/m3, which was significantly higher than the median of 0.04 mg/m3 for subjects who had respirators with a filter.
The median for the concentration of IL-6 in the nasal lavage fluid increased after exposure from 0.5 to 5.9 pg/ml in subjects with respirators without a particle filter (P<0.05).
The increase of the concentration of IL-6 was significantly correlated with the dust concentration.
A decrease in transfer factor of the lung was significantly correlated with daily time weighted average concentrations of terpenes.
Conclusion-The findings suggest that healthy volunteers, exposed to air contaminants in a sawmill, show a slight inflammatory reaction.
Also, the results of the study indicate the importance of decreasing the concentrations of wood dust in the work environment.
Mots-clés Pascal : Scierie, Fumée, Poussière, Pollution intérieur, Exposition professionnelle, Toxicité, Court terme, Homme, Interleukine 6, Cytokine, Nez, Poumon, Inflammation, ORL pathologie, Appareil respiratoire pathologie, Médecine travail
Mots-clés Pascal anglais : Saw mill, Fumes, Dust, Indoor pollution, Occupational exposure, Toxicity, Short term, Human, Interleukin 6, Cytokine, Nose, Lung, Inflammation, ENT disease, Respiratory disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0415187
Code Inist : 002B03L03. Création : 10/04/1997.