There are very limited data on overall epidemiology of ARF.
It is crucial to know the incidence, etiology and clinical features of ARF to promote prevention strategies and to implement adequate resources for the management of this entity.
During a nine month period, a collaborative prospective protocol with 98 variables was developed to assess all ARF episodes encountered in the 13 tertiary-care hospitals in Madrid, Spain (covering 4.2 million people of over 14 years of age).
ARF was considered when a sudden rise in serum creatinine concentration (SCr) to more than 177 mumol/liter was found in patients with normal renal function, or when the sudden rise (50% or more) was observed in patients with previous mild-to-moderate chronic renal failure (SCr<264 mumol/liter).
Of the 748 cases of ARF studied, 665 episodes presented in inhabitans from the Madrid area.
This gives an overall incidence of ARF of 209 cases per million population (p.m.p. ; 95% Cl 195 to 223).
The incidence of acute tubular necrosis (ATN) was 88 cases p.m.p. (95% CI 79 to 97), prerenal ARF 46 p.m. p (95% CI 40 to 52), acute-onset chronic ARF 29 p.m.p. (95% Cl 24 to 34), and obstructive ARF 23 p.m.p. (95% Cl 19 to 27).
The mean age was 63 ± 17 years.
The most frequent causes of ARF were ATN (45%), prerenal (21%), acute-onset chronic renal failure (12.7%) and obstructive ARF (10%). Renal function was normal at admission in 48% of patients who later developed ARF. (...)
Mots-clés Pascal : Insuffisance rénale, Aigu, Incidence, Etiologie, Epidémiologie, Pronostic, Modalité traitement, Etude multicentrique, Adolescent, Homme, Adulte, Espagne, Europe, Echelon régional, Appareil urinaire pathologie, Rein pathologie
Mots-clés Pascal anglais : Renal failure, Acute, Incidence, Etiology, Epidemiology, Prognosis, Application method, Multicenter study, Adolescent, Human, Adult, Spain, Europe, Regional scope, Urinary system disease, Renal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0415154
Code Inist : 002B14A05. Création : 10/04/1997.