An independent and updated historical cohort mortality study was conducted among chemical plant workers to investigate further an association between exposures to formaldehyde and particulates and cancers of the nasopharynx and lung reported in an earlier National Cancer Institute study of the same plant.
Methods-Subjects were 7359 workers who were first employed between 1941 and 1984 in a factory in Wallingford, Connecticut where formaldehyde was used.
Vital status was determined on 31 December 1984 for 96% of the cohort and death certificates were obtained for 93% of 1531 known deaths.
Exposures of individual workers were estimated quantitatively for formaldehyde, product particulates, and non-product particulates, and qualitatively for pigment.
Statistical analyses focused on 6039 white men in 1945-84.
Cohort data that could not have been included in the National Cancer Institute study were also analysed separately.
Mortality among long term workers (employed = 1 y) was generally similar to or more favourable than that of the general population, and there was little evidence of a relation between either rates of lung cancer or standardised mortality ratios (SMRs) and several measures of exposure to formaldehyde, particulates, and pigment.
For several causes including lung cancer, death rates among short term workers (employed<1 y) were significantly increased. (...)
Mots-clés Pascal : Formaldéhyde, Exposition professionnelle, Mortalité, Industrie chimique, Homme, Epidémiologie, Tumeur maligne, Connecticut, Etats Unis, Amérique du Nord, Amérique, Médecine travail
Mots-clés Pascal anglais : Formaldehyde, Occupational exposure, Mortality, Chemical industry, Human, Epidemiology, Malignant tumor, Connecticut, United States, North America, America, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0413115
Code Inist : 002B03L06. Création : 10/04/1997.