Study of employees with anhydride-induced respiratory disease after removal from exposure.
The purpose of this study was to determine the clinical and immunologic status of hexahydrophthalic anhydride (HHPA) - exposed employees who had developed an immunologic respiratory disease and who have been removed from exposure for at least 1 year.
In a surveillance study spanning 4 years, we identified 28 employees with HHPA-induced immunologic respiratory disease who had been removed from exposure for at least 1 year.
Seven had asthma, nine had hemorrhagic rhinitis, four had both, and eight had allergic rhinitis alone.
Respiratory symptoms were assessed by physician-administered questionnaires.
For each employee, a physical examination, spirometry, and chest roentgenograph were performed.
Antibody against HHPA conjugated to human serum albumin (HHP-HSA) was measured using an enzyme-linked immunosorbent assay.
Symptoms, signs, and spirometry normalized in all but one employee.
There were no chest-roentgenograph findings at follow-up that could be attributed to HHPA.
There was a decline in antibody titer for both immunoglobulin E and G against HHP-HSA.
In this group of 28 employees, there was only one employee with mild asthma after removal from exposure for at least 1 year.
Although specific antibody was still present in many, the titers were generally lower at follow-up than at presentation.
Mots-clés Pascal : Anhydride organique, Exposition professionnelle, Toxicité, Appareil respiratoire pathologie, Homme, Arrêt exposition, Surveillance, Etude longitudinale, Exploration immunologique, Médecine travail, Allergie, Immunopathologie, Isobenzofurane-1,3-dione(perhydro)
Mots-clés Pascal anglais : Organic anhydride, Occupational exposure, Toxicity, Respiratory disease, Human, Exposure stopping, Surveillance, Follow up study, Immunological investigation, Occupational medicine, Allergy, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0405663
Code Inist : 002B03L06. Création : 10/04/1997.