Hyperhomocysteinaemia and premature coronary artery disease in the Chinese.
Objectives-To examine the prevalence of hyperhomocysteinaemia and compare it with the classic risk factors and vitamin status in Hong Kong Chinese patients with premature atherosclerotic coronary artery disease.
Setting-General hospital and community.
Subjects-Forty five patients (39 males) with significant coronary artery disease confirmed by angiography (32 post myocardial infarction) and 23 healthy volunteers (17 male), all aged less than 55 years.
Intervention-standardised methionine-loading test.
Main outcome measures-Coronary artery disease, risk factors.
More patients than controls had fasting hyperhomocysteinaemia (10/45 v 2/23, P=0.122), post-methionine hyperhomocysteinaemia (17/45 v 1/23, P=0.008), and an abnormal response to methionine (15/45 v 1/23, P=0.015).
A history of smoking was more frequent in patients (3/23 v 25/45, P=0.002).
Sixteen of 17 patients with hyperhomocysteinaemia but only nine of 28 with normohomocysteinaemia were smokers (P=0.0002).
Fasting plasma cholesterol concentrations (mean (SD)) were higher in hyperhomocysteinaemic patients (6.41 (1.58) mmol/l) than in controls (5.53 (0.90) mmol/l) (P=0.042).
Serum vitamin B-12 was not reduced and serum folate was higher in hyperhomocysteinaemic patients (35 (4) nmol/l) than normohomocysteinaemic patients (26 (9) nmol/l) (P=0.009). (...)
Mots-clés Pascal : Cardiopathie coronaire, Trouble métabolisme, Homocystéine, Hong Kong, Asie, Association morbide, Epidémiologie, Adulte, Homme, Mongoloïde, Facteur risque, Aminoacide, Appareil circulatoire pathologie, Métabolisme pathologie, Hyperhomocystéinémie
Mots-clés Pascal anglais : Coronary heart disease, Metabolic disorder, Hong Kong, Asia, Concomitant disease, Epidemiology, Adult, Human, Mongoloid, Risk factor, Aminoacid, Cardiovascular disease, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0404940
Code Inist : 002B22D01. Création : 10/04/1997.