During the baseline period (1985-1988) of a prospective study, midcycle and luteal-phase estrogens and progestins were measured in 175 healthy women aged 21-36 years with spontaneous, cyclic menses in Brooklyn, New York.
Subjects contributed daily first-morning urine specimens and three blood specimens during a single menstrual cycle monitored by basal body temperature.
Hormone levels were compared according to age, race, and levels of known or suspected breast cancer risk factors.
Late age at menarche was associated with increased urinary and serum progestin levels.
Increased body weight was associated with decreased progestin levels, even in ovulatory women.
Neither weight nor age at menarche was related to estrogen levels.
Cigarette smoking was associated with decreased midcycle and luteal-phase estradiol levels.
No other factors were associated with differences in any of the hormones measured either midcycle or during the luteal phase, despite good statistical power to detect moderate differences.
Sources of individual variability in ovarian steroid levels remain unexplained.
These data do not support hypotheses that breast cancer risk factors act through an effect on ovarian hormones during the middle reproductive years.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Oestrogène, Progestatif, Hormone stéroïde sexuelle, Hormone ovarienne, Cycle menstruel, Femme, Homme, Période activité génitale, New York, Etats Unis, Amérique du Nord, Amérique, Glande mammaire pathologie, Facteur prédictif
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Estrogen, Progestagen, Sex steroid hormone, Ovarian hormone, Menstrual cycle, Woman, Human, Sexually active period, New York, United States, North America, America, Mammary gland diseases, Predictive factor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0398486
Code Inist : 002B20E02. Création : 10/04/1997.