Differences in risk factors for epithelial ovarian cancer by histologic type : Results of a case-control study.
A case-control study of associations between dietary and reproductive factors and cancer of the ovary was conducted during 1989-1992 in metropolitan Toronto and nearby areas of southern Ontario, Canada.
In total, 450 women aged 35-79 years with histologically verified new primary epithelial ovarian cancers were interviewed concerning their reproductive history and dietary practices.
Over the same time period, 564 randomly selected population controls, frequency-matched to the cases according to three 15-year age groups, were also interviewed.
Continuous unconditional logistic regression methods were used for analysis.
It was found that childbearing and use of oral contraceptives were associated with significant decreasing trends in the risk of epithelial ovarian cancer of all principal histologic types except mucinous tumors.
For each full-term pregnancy, the odds ratio was 0.76 (95% confidence interval (CI) 0.69-0.85) for nonmucinous tumors and 1.03 (95% CI 0.88-1.21) for mucinous tumors ; for each year of oral contraceptive use, the odds ratio was 0.89 (95% CI 0.85-0.93) for nonmucinous tumors and 0.98 (95% Cl 0.93-1.04) for mucinous tumors (p=0.00051 and p=0.0040, respectively, for the difference in odds ratios between mucinous and nonmucinous tumors).
Saturated fat intake also appeared to convey greater increased risk for women with mucinous tumors than for women with neoplasms of other histologic types (p=0.029). (...)
Mots-clés Pascal : Tumeur maligne, Ovaire, Cellule épithéliale, Epidémiologie, Type histologique, Femme, Homme, Facteur risque, Canada, Amérique du Nord, Amérique, Alimentation, Parité, Contraceptif, Voie orale, Appareil génital femelle pathologie, Ovaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Ovary, Epithelial cell, Epidemiology, Histological type, Woman, Human, Risk factor, Canada, North America, America, Feeding, Parity, Contraceptive, Oral administration, Female genital diseases, Ovarian diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0398484
Code Inist : 002B20C02. Création : 10/04/1997.