A 50-y-old male worker developed an asthmatic reaction after exposure to bichromate in a metal-plating plant.
Evaluation included skin tests, bronchial provocation tests, and specific radioallergosorbent tests with metal salts.
A 49-y-old worker who suffered from hard metal asthma was the control.
These workers were not atopic, and they exhibited similar bronchial hyperresponsiveness in methacholine-PC20 (74 mg/ml versus 81 mg/ml, respectively) and IgE titers (129 lU/ml versus 130 lU/ml).
Positive intradermal and patch tests to bichromate were found in the subject.
A bronchial provocation test with inhalation of. 01% bichromate produced an immediate decrease in forced vital capacity in 1 s, followed by a rapid recovery within 5 min absent any treatment.
There was no reaction to cobalt (1% cobalt chloride) or to nickel (2% nickel sulfate) salts.
In the control, a positive bronchial provocation occurred (absent chromium) with cobalt and nickel.
Administration of a subcutaneous preparation of 1 mg atropine sulfate or of 1 puff of disodium cromoglycate or bêta-stimulant reduced bronchial responsiveness to methacholine-PC20 and no asthmatic reaction occurred following inhalation of 1% bichromate.
No blocking of asthmatic reaction occurred after pretreatment with beclomethasone dipropionate inhalation.
Administration of propranolol, however, potentiated the acute bronchoconstriction induced by bichromate. (...)
Mots-clés Pascal : Chrome, Métal lourd, Toxicité, Asthme, Dichromate, Homme, Etude cas, Revêtement métallique, Exposition professionnelle, Industrie métallurgique, Médecine travail, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Chromium, Heavy metal, Toxicity, Asthma, Dichromates, Human, Case study, Metal coating, Occupational exposure, Metallurgical industry, Occupational medicine, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0398364
Code Inist : 002B03L05. Création : 10/04/1997.