To examine the relation of cigarette smoking and alcohol consumption to serum fatty acid levels, the authors conducted a cross-sectional study of 190 men who were enrolled in the Multiple Risk Factor Intervention Trial between 1973 and 1976.
After controlling for dietary fat, cholesterol, energy intake, and other potential confounders, the authors found that smoking and alcohol intake were associated with the serum cholesterol ester and phospholipid levels of several fatty acids.
As the number of cigarettes smoked per day increased, the levels of cholesterol ester and phospholipid palmitoleic acid (16 : 1) and oleic acid (18 : 1) and the levels of phospholipid dihomogammalinolenic acid (20 : 3) and omega-9 eicosatrienoic acid (20 : 3) increased (all p's ¾ 0.01).
Serum levels of phospholipid omega-3 docosahexaenoic acid (22 : 6) and cholesterol ester and phospholipid arachidonic acid (20 : 4) were inversely associated with smoking (all p's ¾ 0.01).
As the number of alcoholic drinks per week increased, levels of cholesterol ester and phospholipid palmitic acid (16 : 0) and oleic acid (18 : 1), cholesterol ester myristic acid (14 : 0), and phospholipid palmitoleic acid (16 : 1), adrenic acid (22 : 4), and omega-9 eicosatrienoic acid (20 : 3) increased (all p's<0.05), whereas levels of cholesterol ester and phospholipid linoleic acid (18 : 2) and phospholipid stearic acid (18 : 0) and the serum polyunsaturated fat : saturated fat ratio decreased (all p's ¾ 0.01). (...)
Mots-clés Pascal : Tabagisme, Consommation, Ethanol, Epidémiologie, Toxicité, Acide gras, Sérum, Taux, Lipide, Cholestérol, Phospholipide, Homme, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Tobacco smoking, Consumption, Ethanol, Epidemiology, Toxicity, Fatty acids, Serum, Rate, Lipids, Cholesterol, Phospholipid, Human, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0398203
Code Inist : 002B03E. Création : 10/04/1997.