Organochlorines (i.e., synthetic chlorinated hydrocarbon compounds) are widespread, environmental contaminants that are present throughout the United States.
Strong epidemiological evidence has linked occupational exposure to a high incidence of non-Hodgkin's lymphoma.
Recently, it has been postulated that exposure to organochlorines increases the risk of developing breast cancer.
Human data on this issue remain insufficient, but recent results are very consistent.
Observations in human populations of the immunotoxic and hormone-mimicking properties of some organochlorines add biological plausibility to the epidemiologic findings.
Limitations in out ability to measure organochlorine exposure still preclude a quantitative risk assessment, relative to these cancer endpoints.
Public health action with respect to restriction of ongoing production and use of organochlorines, however, appears warranted for purposes of prevention.
Mots-clés Pascal : Organochloré, Toxicité, Lymphome non hodgkinien, Tumeur maligne, Glande mammaire, Homme, Carcinogène, Epidémiologie, Pesticide, Biphényle(polychloro), Hydrocarbure chloré, Hémopathie maligne, Lymphoprolifératif syndrome, Glande mammaire pathologie
Mots-clés Pascal anglais : Organochlorine compounds, Toxicity, Non Hodgkin lymphoma, Malignant tumor, Mammary gland, Human, Carcinogen, Epidemiology, Pesticides, Polychlorobiphenyl, Chlorocarbon, Malignant hemopathy, Lymphoproliferative syndrome, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0397992
Code Inist : 002B19B. Création : 10/04/1997.