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  1. Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila, The Philippines.

    Article - En anglais

    Antibodies against hepatitis C virus (HCV) were detected in 18 (23%) of 800 sera from commercial blood donors and 23 (4.6%) of 502 sera from inmates in Metro Manila, the Philippines.

    The difference in the antibody prevalence between the two groups was statistically significant (P<0.05).

    HCV RNA was detected in 14 (78%) of the 18 antibody-positive sera from blood donors and 19 (83%) of the 23 antibody-positive sera from inmates.

    Genotype analysis revealed that HCV-lb (50%) was most common among blood donors, followed by HCV-1a (36%) and HCV-2a (7%). Among inmates, on the other hand, HCV-la (68%) was most common, followed by HCV-1b (11%), HCV-2a (5%) and HCV-2b (5%). Overall, HCV-la and HCV-1b appeared to be predominant among them.

    Thus, the genotype prevalence in the Philippines was distinct from those in other Southeast Asian countries such as Thailand, Vietnam and Indonesia, and also distinct from those in the Far East including Taiwan, Mainland China and Japan.

    Mots-clés Pascal : Virus hépatite C, Flaviviridae, Virus, Génotype, Epidémiologie moléculaire, Prévalence, Donneur sang, Homme, Philippines, Asie, Hépatite virale C, Virose, Infection, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Hepatitis C virus, Flaviviridae, Virus, Genotype, Molecular epidemiology, Prevalence, Blood donor, Human, Philippine Islands, Asia, Viral hepatitis C, Viral disease, Infection, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0396799

    Code Inist : 002B05C02G. Création : 10/04/1997.