Increased prevalence of systemic sclerosis in a native American Tribe in Oklahoma : Association with an Amerindian HLA haplotype.
To investigate a high prevalence of systemic sclerosis (SSc ; scleroderma) in a well-defined population of 21,255 Choctaw Indians residing in 8 southeastern Oklahoma counties who were « users » of Indian Health Services.
A case-control study of 12 SSc cases and 48 matched non-SSc controls (4 per case) was conducted to investigate potential occupational, residential, and infectious exposures, as well as genetic factors which might predispose to SSc.
HLA class II alleles were determined by DNA oligotyping, and class I and III alleles were defined serologically.
The prevalence of SSc in full-blooded Choctaws was at least 8/1,704, or 469/100,000 (95% confidence interval [95% CI] 203-930) over the 4-year interval 1990-1994 and was significantly higher than that among non-full-blooded Choctaws (6/19,551, or 31/100,000) (P=0.00001, odds ratio [OR]=15.4,95% CI 4.9-49.8).
The overall prevalence of SSc in Oklahoma Choctaws (66/100,000) also was significantly higher than that in other Native Americans in Oklahoma (9.5/100,000) (P=10-6, OR=6.95,95% CI 3.3-13.7), who showed a prevalence similar to that reported for whites (2.1-25.3/100,000).
Among the SSc cases, there was striking homogeneity of disease expression with the majority exhibiting diffuse scleroderma, pulmonary fibrosis, and autoantibodies to topoisomerase I. No environmental exposures were found to be in excess among cases versus controls. (...)
Mots-clés Pascal : Sclérodermie, Homme, Facteur risque, Epidémiologie, Oklahoma, Etats Unis, Amérique du Nord, Amérique, Ethnie, Amérindien, Phénotype, Système HLA-DR, Système histocompatibilité majeur, Prévalence, Facteur milieu, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie
Mots-clés Pascal anglais : Scleroderma, Human, Risk factor, Epidemiology, Oklahoma, United States, North America, America, Ethnic group, Amerindian, Phenotype, HLA-DR-System, Major histocompatibility system, Prevalence, Environmental factor, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0395806
Code Inist : 002B07. Création : 10/04/1997.